Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination

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Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination

OBJECTIVE We aimed to examine the regulation of lipocalin-2 (LCN2) in multiple sclerosis (MS) and its potential functional relevance with regard to myelination and neurodegeneration. METHODS We determined LCN2 levels in 3 different studies: (1) in CSF and plasma from a case-control study comparing patients with MS (n = 147) with controls (n = 50) and patients with relapsing-remitting MS (n = ...

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Demyelination versus remyelination in progressive multiple sclerosis.

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Multiple sclerosis (MS) is an immune-mediated disorder of the central nervous system that results in destruction of the myelin sheath that surrounds axons and eventual neurodegeneration. Current treatments approved for the treatment of relapsing forms of MS target the aberrant immune response and successfully reduce the severity of attacks and frequency of relapses. Therapies are still needed t...

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Remyelination is extensive in a subset of multiple sclerosis patients.

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ژورنال

عنوان ژورنال: Neurology - Neuroimmunology Neuroinflammation

سال: 2016

ISSN: 2332-7812

DOI: 10.1212/nxi.0000000000000191